Globe-trotting Christine wakes up one ordinary day to find her biological clock has gone off with a vengeance. But for a commitment-phobe on the wrong side of 40, the road to motherhood is strewn with chaos, calamity and smoked-out eggs.

When she turns to her lifelong friends Margo and Mikki for support, they are equally embattled. Margo zealously guards the door to her recently emptied nest, and Mikki frantically fights her evil twin foes—Sagging and Drooping. Collectively, the girls are a force to be reckoned with, and they take on the might of Mother Nature with hilarious results.