Brian Timilty is running for mayor on an anti-superhero ticket, and the amazing Spider-Man is his biggest target. But Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York’s mobs. To ensure his success, Stewart hires two of Spider-Man’s deadliest foes, Electro and the Rhino, and executes a plan guaranteed to keep the wall-crawler from interfering with his grand designs: He frames Spider-Man for a grisly murder!

Forced into hiding, Spider-Man must find a way to clear his name without being shot on sight, for he is wanted dead or alive.